BioengineeringbioRxiv
Biological Plasticity Rescues Target Activity in CRISPR Knockouts
A. H. Smits, F. Ziebell, G. Joberty…·W. Huber
The paper quantifies residual protein expression in CRISPR-Cas9 knockouts using RNA-seq and SPS-MS3, identifying mechanisms of partial protein preservation and functional retention.
DOI 10.1038/s41592-019-0614-5