H. Sun

GDF15 knockout does not substantially impact perinatal body weight or neonatal outcomes in mice

This study examines the role of GDF15 in pregnancy and neonatal outcomes using a knockout mouse model, finding no major effects on body weight or survival.

Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain

This study identifies ultra-potent Omicron-specific antibodies targeting the N1/N2 loop of the Spike NTD, which neutralize SARS-CoV-2 by competing with ACE2 and blocking S1 shedding, but are evaded by BA.2.86 and BA.2.87.1 sublineages.

Shrimp Hemocyanin elicits a potent humoral response in mammals and is favorable to hapten conjugation

This study shows shrimp hemocyanin (SHC) can replace keyhole limpet hemocyanin (KLH) as a carrier protein for hapten conjugation, offering better solubility and comparable immunogenicity in mammals.

First-male sperm precedence in polyandrous Spodoptera frugiperda allows sterile males induce population suppression

This study identifies first-male sperm precedence in fall armyworms and shows sterile males can suppress pest populations through sperm competition mechanisms.

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

Multiomics mapping and characterization of cellular senescence in aging human skeletal muscle uncovers a novel senotherapeutic for sarcopenia

This study uses single-nucleus multiomics to characterize senescence in human skeletal muscle, identifies SASP factors, and proposes Maraviroc as a senotherapeutic for sarcopenia.

Akt2 deficiency impairs Th17 differentiation, augments Th2 differentiation, and alters the peripheral response to immunization

This study shows Akt2 deficiency impairs Th17 differentiation, enhances Th2 differentiation, and reduces peripheral immune responses to immunization.

Mass mortality associated with Carpione Rhabdovirus in golden pompano (Trachinotus ovatus) in China: First report

This study reports the first natural infection of Carpione Rhabdovirus in golden pompano fish in China, associated with high mortality and characterized by viral morphology and genetic analysis.

Omicron-specific naive B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine

The paper investigates how Omicron-specific naive B cell maturation after breakthrough infection alleviates immune imprinting from inactivated SARS-CoV-2 vaccines.

Megabarcoding reveals a tale of two very different dark taxa along the same elevational gradient

The paper uses megabarcoding to show that two Diptera taxa have distinct spatio-temporal distributions along an elevational gradient in a temperate forest.

Multiple Omics Find New Cecal Microbial Features Associated with Feed Efficiency in Ducks

The paper identifies microbial and metabolic differences associated with feed efficiency in ducks using metagenomics, transcriptomics, and metabolomics.

Varying phylogenetic signal in susceptibility to four bacterial pathogens across species of Drosophilidae

The paper examines susceptibility to four bacterial pathogens across 36 Drosophilidae species, finding strong phylogenetic signal in susceptibility, particularly for Providencia rettgeri.

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

This study analyzes the humoral immune response to SARS-CoV-2 XBB and JN.1 lineages, showing JN.1 elicits superior neutralization and highlights the need for JN.1-based vaccine boosters.

The gut microbiota is essential for Trichinella spiralis-evoked suppression of colitis

This study shows that Trichinella spiralis infection protects against colitis in mice by altering the gut microbiota, increasing SCFA-producing bacteria, and enhancing goblet cell differentiation and IL-10 levels.

GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding

This study identifies GGCX as a key factor enabling EA H1N1 SIV adaptation to human-type -2,6 sialic acid receptors through HA carboxylation, suggesting it as a potential antiviral target.

Super Pangenome of Grapevines Empowers Improvement of the Oldest Domesticated Fruit

The paper assembles and annotates haplotype-resolved genomes of grapevines to uncover genetic diversity and disease resistance mechanisms, identifying structural variants linked to downy mildew resistance.

Unraveling the gut microbiota of Tibetan chickens: insights into highland adaptation and ecological advantages

This study compares the gut microbiota of Tibetan chickens from different environments to identify adaptations to high-altitude conditions.

PRMT5 deficiency disturbs Nur77 methylation to inhibit endometrial stromal cell differentiation in recurrent implantation failure

This study shows PRMT5 deficiency disrupts Nur77 methylation, impairing endometrial stromal cell differentiation and contributing to recurrent implantation failure.

The Effect of Adrenalectomy on Bleomycin-Induced Pulmonary Fibrosis in Mice

This study investigates the effect of adrenalectomy on bleomycin-induced pulmonary fibrosis in mice, finding that adrenalectomy reduces lung remodeling but not collagen deposition.

Comparative transcriptome analysis provides insights into the resistance regulation mechanism and inhibitory effect of fungicide phenamacril in Fusarium asiaticum

This study identifies DEGs and their roles in phenamacril resistance in Fusarium asiaticum through comparative transcriptome analysis of sensitive and resistant strains.

Skeletal Muscle Stem Cells Modulate Niche Function in Duchenne Muscular Dystrophy through YY1-CCL5 Axis

This study shows that skeletal muscle stem cells modulate their niche in Duchenne muscular dystrophy via the YY1-CCL5 axis, influencing macrophage and fibro-adipogenic progenitor behavior and offering a therapeutic target.

Aerosolized α1 adrenoreceptor antagonism does not affect experimentally induced lung fibrosis in animal models

This study tests if inhaled terazosin, an α1 adrenoreceptor antagonist, reduces lung fibrosis in animal models but finds no significant effect.

Not dasycladalean alga, but an Odyssey of the earliest Phanerozoic animal reef-builders

The paper reclassifies Protomelission? sp. as archaeocyath-like sponges, challenging previous interpretations and providing insights into early animal reef-building.

UBE2N is essential for maintenance of skin homeostasis and suppression of inflammation

This study shows that UBE2N is crucial for skin homeostasis and inflammation suppression, with its loss causing inflammatory skin defects and identifying IRAK1/4 as a therapeutic target.

Hammerhead-type FXR agonists induce an eRNA FincoR that ameliorates nonalcoholic steatohepatitis in mice

This study identifies a novel FXR-induced eRNA, FincoR, which mediates the therapeutic effects of hammerhead-type FXR agonists in NASH mice.

Universal Digital High Resolution Melt for the detection of pulmonary mold infections

This paper introduces U-dHRM, a method for rapid detection of pulmonary mold infections with high accuracy and speed, identifying 73% of suspected cases.

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

This study identifies breast cancer subtypes and their lineage origins by analyzing chromatin accessibility and transcriptional dynamics using multi-omic techniques.

Long-Term In Vivo Molecular Monitoring Using Aptamer-Graphene Microtransistors

This paper introduces AGMs for long-term in vivo molecular monitoring, demonstrating detection of dopamine and serotonin in blood and in vivo dopamine release in mice for over a week.

Aminoglycoside heteroresistance in Enterobacter cloacae is driven by the cell envelope stress response.

This study identifies the CpxRA cell envelope stress response as the driver of aminoglycoside heteroresistance in E. cloacae, showing its role in transient resistance and MIC elevation.

From head to tail - Atomistic mechanism of long-range coupling from the cytosolic sensor domain to the selectivity filter in TREK K2P channels

The paper reveals the atomistic mechanism of long-range coupling between the cytosolic sensor domain and the selectivity filter in TREK K2P channels, showing how conformational changes and phosphorylation regulate channel activity.