Heat Shock Factor 1 (HSF1) as a new tethering factor for ESR1 supporting its action in breast cancer.
N. Vydra, P. Janus, P. Kus, T. Stokowy, K. Mrowiec, A. Toma-Jonik, A. Krzywon, A. J. Cortez, B. Wojtas, B. Gielniewski, R. Jaksik, M. Kimmel, W. Widlak
This study shows HSF1 enhances ESR1's genomic action in breast cancer, increases transcriptome diversity, and together they predict poor prognosis in ER-negative cancers.
bioRxiv · May 6, 2021Cancer Biology