B. Wojtas

Molecular fingerprints in the hippocampus of alcohol seeking during withdrawal

The paper identifies molecular differences in the hippocampus between AUD-prone and AUD-resistant mice during alcohol withdrawal.

Comprehensive analysis of the transcription factor REST regulatory networks in IDH-mutant and IDH-wild type glioma

This study identifies differences in REST regulatory networks between IDH-mutant and IDH-wild type gliomas, highlighting distinct gene expression control mechanisms.

Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications.

The paper identifies c-Jun as a key transcription factor regulating genes critical for glioblastoma, with DNA methylation modulating its activity in GBM cells.

Heat Shock Factor 1 (HSF1) as a new tethering factor for ESR1 supporting its action in breast cancer.

This study shows HSF1 enhances ESR1's genomic action in breast cancer, increases transcriptome diversity, and together they predict poor prognosis in ER-negative cancers.

Epigenetic regulation of differentially expressed genes between various glioma types

The paper integrates epigenetic and transcriptomic data to identify gene regulatory networks and chromatin organization differences between low and high grade gliomas.

The novel, recurrent mutation in the TOP2A gene results in the enhanced topoisomerase activity and transcription deregulation in glioblastoma

The paper identifies a novel TOP2A mutation in glioblastomas that enhances DNA binding and transcriptional activity, correlating with poorer patient survival.

Mapping chromatin accessibility and active regulatory elements reveals new pathological mechanisms in human gliomas

The paper maps chromatin accessibility and regulatory elements in human gliomas to identify new epigenetic mechanisms driving cancer progression.