ClpS directs degradation of primary N-end rule substrates in Mycolicibacterium smegmatis
C. J. Presloid, J. Jiang, P. Kandel, H. R. Anderson, P. C. Beardslee, T. M. Swayne, K. R. Schmitz
This study identifies ClpS as a key regulator of primary N-end rule proteolysis in Mycolicibacterium smegmatis, showing it binds canonical N-degrons and enhances substrate specificity for ClpC1P1P2 protease.
bioRxiv · Jun 12, 2024 · PreprintBiochemistry