J. Jiang

Substrate specificity and protein stability drive the divergence of plant-specific DNA methyltransferases

This study investigates how CMT2 and CMT3 diverge in substrate specificity and protein stability, revealing evolutionary mechanisms of DNA methylation in plants.

Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer

This paper introduces BSJ-5-63, a PROTAC that degrades CDK12, CDK7, and CDK9, inducing BRCAness and blocking AR signaling to enhance PARP inhibitor sensitivity in prostate cancer.

The Hippo pathway effector YAP inhibits NF-kB signaling and ccRCC growth by opposing ZHX2

This study shows YAP inhibits NF-κB signaling and ccRCC growth by blocking ZHX2, a co-factor of NF-κB, and competes with ZHX2 for binding to p65.

ClpS directs degradation of primary N-end rule substrates in Mycolicibacterium smegmatis

This study identifies ClpS as a key regulator of primary N-end rule proteolysis in Mycolicibacterium smegmatis, showing it binds canonical N-degrons and enhances substrate specificity for ClpC1P1P2 protease.

Identification and Characterization of the Lipoprotein N-acyltransferase in Bacteroides

This paper identifies and characterizes Lnb, a lipoprotein N-acyltransferase in Bacteroides, showing its role in lipoprotein biosynthesis and its impact on bacterial growth and polysaccharide degradation.

Structural and Biophysical Dynamics of Fungal Plasma Membrane Proteins and Implications for Echinocandin Action in Candida glabrata

This study investigates the structural and dynamic organization of plasma membrane proteins in Candida glabrata using cryo-ET and live cell imaging, revealing how echinocandin drugs affect their distribution and function.

Cyclic di-GMP as an Antitoxin Regulates Bacterial Genome Stability and Antibiotic Persistence in Biofilms

The paper identifies a toxin-antitoxin system in biofilms where c-di-GMP regulates genome stability and antibiotic persistence by controlling HipH activity.

Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

This study identifies PRMT inhibitors as effective combinational therapies with PARP inhibitors to sensitize HR-proficient ovarian and breast cancer cells to treatment.

ZBTB11 Depletion Targets Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC

This study develops ZBTB11 degraders to target metabolic vulnerabilities in K-Ras inhibitor-resistant PDAC, showing improved anti-cancer activity with reduced toxicity to neurons.

Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1

This study investigates LARP1's preference for singly guanylated poly(A) RNA sequences and shows cyclic di-nucleotides bind with sub-micromolar affinity.

Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for AML therapy

This study identifies PTPN2 as a therapeutic target in AML, discovers a selective inhibitor K73, and demonstrates its efficacy in reducing AML burden in vitro and in vivo.

Traction Force Microscopy with DNA FluoroCubes

This paper introduces FluoroCubes as fiducial markers for traction force microscopy, enabling high-resolution force mapping with improved sensitivity and compatibility with TIRF microscopy.

Novel Polymycoviruses Are Encapsidated in Filamentous Virions

This paper identifies and characterizes three novel polymycoviruses in phytopathogenic fungi, confirming they are encapsidated in filamentous virions with P-A-S-rich coat proteins.

Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection

This study evaluates hybrid immunity against the Omicron variant JN.1 11 months after breakthrough infection, showing heterogeneous responses and increased neutralization following reinfection.

Super Pangenome of Grapevines Empowers Improvement of the Oldest Domesticated Fruit

The paper assembles and annotates haplotype-resolved genomes of grapevines to uncover genetic diversity and disease resistance mechanisms, identifying structural variants linked to downy mildew resistance.

Directed biomechanical compressive forces enhance fusion efficiency in model placental trophoblast cultures

The paper shows that mechanical compressive forces enhance fusion in trophoblast cell cultures, suggesting a role for biomechanics in placental development.

Revealing nanoscale structure and interfaces of protein and polymer condensates via cryo-electron microscopy

This study uses cryo-EM to analyze nanoscale structures of protein and polymer condensates, revealing core-shell morphologies and internal inhomogeneities.

Development of a qPCR assay and a LAMP assay for Verticillium longisporum detection and a triplex qPCR assay for simultaneous detection of V. longisporum, Leptosphaeria biglobosa and L. maculans from canola samples

Identification and classification of the genomes of novel Microviruses in a poultry slaughterhouse

This study identifies 98 novel microvirus genomes from a poultry slaughterhouse, classifies them into 6 new subfamilies and 3 higher-level units, and expands their known host range.

Functional consequences of reductive protein evolution in a minimal eukaryotic genome

This study examines how protein reduction in microsporidia affects function, showing that most proteins cannot complement yeast orthologs and are more reduced in length.

Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma

This study evaluates the therapeutic potential of RMC-7977, a broad-spectrum RAS inhibitor, in pancreatic ductal adenocarcinoma models, showing strong anti-tumor effects with minimal impact on normal tissues.

Experimental structures of antibody/MHC-I complexes reveal details of epitopes overlooked by computational prediction

X-ray structures of anti-MHC-I/MHC-I complexes define epitopes overlooked by computational prediction.

Epigenetic Small-Molecule Screen for Inhibition and Reversal of Acinar Ductal Metaplasia in Mouse Pancreatic Organoids

The paper screens epigenetic small molecules to inhibit and reverse acinar ductal metaplasia in mouse pancreatic organoids, identifying several effective compounds with improved activity over TSA.

Multiplicative frequency and angular speckle reduction in ultrasound imaging

The paper demonstrates multiplicative speckle reduction in ultrasound imaging by combining frequency and angular averaging, achieving ~9x reduction in phantom images and ~6x in human wrist imaging.

METI: Deep profiling of tumor ecosystems by integrating cell morphology and spatial transcriptomics

METI integrates spatial transcriptomics and cell morphology to improve analysis of tumor microenvironments, showing consistent performance across multiple cancer types.

IgG-inspired, multivalent protein-DNA nanostructures for high-affinity, tunable, and reversible binding to biomolecular targets

This paper designs and tests a DNA-based synthetic antibody (nano-synbody) that binds SARS-CoV-2 spike proteins with high affinity and reversibility through multivalency.

A role for JAK2 in mediating cell surface GHR-PRLR interaction

This study investigates the spatiotemporal dynamics of GHR and PRLR on breast cancer cells using dSTORM, revealing that PRLR-GHR interaction is essential for ligand-induced changes in receptor surface availability.

A Biotin Targeting Chimera (BioTAC) System to Map Small Molecule Interactomes in situ

The paper introduces the BioTAC system to map small molecule interactomes in situ, enabling the identification of both direct and complexed binding proteins with high confidence.

The role of neutrophil typing in homeostatic resilience protective model of inflammatory preconditioning

This study investigates the role of IRF4 and IRF5 in neutrophil response during septic peritonitis, showing their involvement in PMN phenotype switching and inflammatory outcomes.

Differential substrate affinity and catabolite repression enable preferential use of urea by ammonia-oxidizing bacteria

The paper shows that ammonia-oxidizing microorganisms use different regulatory strategies for ammonia and urea, enabling coexistence by minimizing competition.