P. Kast

Novel exported bifunctional fusion enzymes with chorismate mutase and cyclohexadienyl dehydratase activity: shikimate pathway enzymes teamed up in no man's land

The paper identifies rare exported bifunctional fusion enzymes combining chorismate mutase and cyclohexadienyl dehydratase in non-pathogenic bacteria, showing no catalytic benefit from fusion and suggesting a signaling role.

What drives chorismate mutase to top performance? Insights from a combined in silico and in vitro study

The paper investigates how the Mycobacterium tuberculosis chorismate mutase achieves high catalytic efficiency through structural and dynamic changes, both in silico and in vitro.

Evolution-based design of chorismate mutase enzymes

This paper demonstrates an evolution-based design process for synthetic enzymes using sequence data, showing that statistical models can generate functional sequences with substantial diversity.