Author

D. Hilvert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein design· 1

Frequent Co-Authors

A. J. Mulholland· 1 shared A. J. P. Scott· 1 shared A. Steinauer· 1 shared C. Stocker· 1 shared E. Wroblewski· 1 shared H. A. Bunzel· 1 shared I. Sharon· 1 shared K. Munro· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperBiochemistry

A. J. Mulholland

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4 papers

Recent·Most cited

Structure and function of a hexameric cyanophycin synthetase 2

L. M. D. Markus, I. Sharon, K. Munro, M. Grogg, D. Hilvert, M. Strauss, M. Schmeing

The paper reports cryo-EM structures of hexameric CphA2 from Stanieria sp., with and without ATP and cyanophycin, and shows how hexamerization enhances cyanophycin synthesis.

bioRxiv · Apr 15, 2023Biochemistry

Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein

S. Tetter, N. Terasaka, A. Steinauer, R. J. Bingham, S. Clark, A. J. P. Scott, N. Patel, M. Leibundgut, E. Wroblewski, N. Ban, P. G. Stockley, R. Twarock, D. Hilvert

This study evolved a bacterial protein into an artificial nucleocapsid that packages and protects mRNA, revealing evolutionary parallels to viruses and potential applications in vaccine delivery.

bioRxiv · Dec 23, 2020Biochemistry

Evolution of dynamical networks enhances catalysis in a designer enzyme

H. A. Bunzel, R. Anderson, D. Hilvert, V. L. Arcus, M. W. van der Kamp, A. J. Mulholland

This study shows that directed evolution of a designer enzyme introduces dynamical changes that increase activation heat capacity and nonlinearity in temperature dependence through correlated dynamical networks.

bioRxiv · Aug 21, 2020Biochemistry

Evolution-based design of chorismate mutase enzymes

W. P. Russ, M. Figliuzzi, C. Stocker, P. Barrat-Charlaix, M. Socolich, P. Kast, D. Hilvert, R. Monasson, S. Cocco, M. Weigt, R. Ranganathan

This paper demonstrates an evolution-based design process for synthetic enzymes using sequence data, showing that statistical models can generate functional sequences with substantial diversity.

bioRxiv · Apr 1, 2020 · PreprintBiochemistry