Tissue of origin detection for cancer tumor using low-depth cfDNA samples through combination of tumor-specific methylation atlas and genome-wide methylation density in graph convolutional neural networks
T. H. Nguyen, N. N. T. Doan, T. H. Tran, L. A. K. Huynh, P. L. Doan, T. H. H. Nguyen, V. T. C. Nguyen, G. T. H. Nguyen, H.-N. Nguyen, H. Giang, L. S. Tran, M. D. Phan
The paper develops a model combining tumor-specific methylation atlas and cfDNA features to improve tissue-of-origin detection in low-depth cfDNA samples.
bioRxiv · Dec 24, 2023Cancer Biology