EccDNA formation is dependent on MMEJ, repressed by c-NHEJ pathway, and stimulated by DNA double-strand break
T. Paulsen, P. Malapati, R. Eki, T. Abbas, A. Dutta
This study quantifies eccDNA formation, showing it depends on MMEJ and is repressed by c-NHEJ, with increased levels from DNA breaks and during S-phase.
bioRxiv · Dec 3, 2020 · PreprintCancer Biology