A. Dutta

Computational screening of T-muurolol for an alternative antibacterial solution against Staphylococcus aureus infections: A state-of-the-art phytochemical-based drug discovery approach

This study identifies T-muurolol as a potential antibacterial agent against Staphylococcus aureus through computational screening, showing interactions with key bacterial proteins and favorable pharmacological properties.

BUTYRATE AMELIORATES INFLAMMATION IN COLON BIOPSY SAMPLES OF IBD PATIENTS AND EXPERIMENTAL COLITIS IN MICE INVOLVING RNA BINDING PROTEIN, AUF1-IL-27 AXIS AND ACCELERATING B1a TO B10 POLARIZATION

This paper shows butyrate enhances B10 cell generation via the AUF1-IL-27 axis in IBD patients and mice, reducing inflammation.

Remodeling Ca2+ dynamics by targeting a promising E-box containing G-quadruplex at ORAI1 promoter in triple-negative breast cancer.

The paper identifies a G-quadruplex in the ORAI1 promoter that regulates transcription and Ca2+ dynamics in triple-negative breast cancer.

Evaluation of melanocyte stem cell population in vitiliginous skin pre- and post-narrow-band UVB phototherapy

This study evaluates melanocyte stem cell and immune cell changes in vitiligo patients before and after narrow-band UVB phototherapy, finding increased MelSC re-population and reduced CD3+ T-cells.

ALTering cancer by triggering telomere replication stress through the stabilization of promoter G-quadruplex in SMARCAL1

This study shows that stabilizing G-quadruplex in SMARCAL1 promoter reduces its expression, increases replication stress, and promotes DNA damage in ALT-positive cancer cells, suggesting G4 stabilizers as potential therapeutics.

A chemically-induced attenuated strain of Candida albicans generates robust protective immune responses and prevents systemic candidiasis development

The paper attenuates Candida albicans using EDTA to create a live vaccine candidate that induces protective immunity and prevents systemic candidiasis in mice.

Bacterial pore-forming toxin pneumolysin drives pathogenicity through shed toxin-loaded host extracellular vesicles

This study shows that pneumolysin-loaded host extracellular vesicles contribute to pneumococcal pathogenesis by inducing cytotoxicity and inflammation.

Phosphate starvation regulates cellulose synthesis to modify root growth

This study shows that phosphate starvation increases cellulose synthesis in Arabidopsis roots, altering cell wall structure and reducing primary root growth through changes in cellulose synthase phosphorylation.

Gestures Of Hunger: Uncovering Intentional Gestural Communication In Free-Ranging Hanuman Langurs

This study identifies intentional gestural communication in Hanuman langurs, showing they use learned gestures to request food from humans and adapt this behavior as a foraging strategy.

Biomechanical comparison of plate materials and designs for subcondylar fracture fixation: An in silico assessment

This study compares plate materials and designs for subcondylar fracture fixation using finite element analysis, finding that double mini plates and titanium alloys provide the best stability.

Systematic characterization of therapeutic vulnerabilities in Multiple Myeloma with Amp1q reveals increased sensitivity to the combination of MCL1 and PI3K inhibitors

Differential expression of miRNAs between Young-Onset and Late-Onset Indian colorectal carcinoma patients

The paper identifies differentially expressed miRNAs between young-onset and late-onset colorectal carcinoma patients and links them to epithelial-mesenchymal transition and tumor progression.

Detect+Track: Robust and flexible software tools for improved tracking and behavioural analysis of fish

The paper introduces Detect+Track, a software tool for accurate fish tracking and behavioural analysis in complex environments.

Increase in primary cilia number and length upon VDAC1 depletion contributes to attenuated proliferation of cancer cells

This study shows that VDAC1 depletion increases primary cilia length and number, which inhibits cell proliferation in cancer cells.

Left or right: Handedness in free-ranging Hanuman langurs (Semnopithecus entellus) residing in an urban ecosystem.

This study examines handedness in free-ranging Hanuman langurs, finding a left-hand bias in adults, challenging the Postural Origin Theory.

Identification of potential selective autophagy receptors from protein-content profiling of autophagosomes

The paper identifies potential selective autophagy receptors and their cargo components using integrated profiling data and structural modeling in HeLa cells.

Composition of nasopharyngeal microbiota in individuals with SARS-CoV-2 infection across three COVID-19 waves in India

This study examines nasopharyngeal microbiota changes in SARS-CoV-2 infected individuals across three waves in India, finding consistent depletion of Rickettsiaceae and increased abundance of certain genera in symptomatic patients.

Biomechanical influence of plate configurations on mandible subcondylar fracture fixation: a finite element study

This study compares the biomechanical performance of five plate configurations for subcondylar fracture fixation under different mastication conditions, finding that double mini and trapezoid plates perform better.

Extracellular caspase-1 regulates hair follicle stem cell migration during wound-healing

This study identifies extracellular Caspase-1 as a chemoattractant that drives hair follicle stem cell migration during wound healing.

FMRP directly interacts with R-loop and shows complex interplay with the DHX9 helicase

The paper was withdrawn due to duplicate submission and is not intended for citation.

Trimethylamine N-oxide (TMAO) enhances substrate mechanical stability probed by single molecule magnetic tweezers

This study investigates how TMAO affects the mechanical stability of proteins using single-molecule magnetic tweezers, finding it increases unfolding force and alters folding kinetics.

Methionine uptake via SLC43A2 transporter is essential for regulatory T lymphocyte survival

The paper identifies methionine uptake via SLC43A2 as essential for Treg survival during IL-2 deprivation, regulated by Notch1.

PBRM1 is a vulnerability in ARID1A deficient multicellular tumor spheroids

The paper identifies PBRM1 as a new vulnerability in ARID1A-deficient multicellular tumor spheroids, showing its role in cell survival and hypoxia gene induction.

Hypoxic response is driven by the BAF form of SWI/SNF

The paper shows hypoxia alters SWI/SNF complex composition, with BAF subunits retained and others downregulated, affecting HIF target gene induction and cell survival.

Genetic Subtypes of Smoldering Multiple Myeloma are associated with Distinct Pathogenic Phenotypes and Clinical Outcomes

This study identifies six genetic subtypes of smoldering multiple myeloma associated with distinct clinical outcomes and progression risks.

A tumor suppressive long noncoding RNA, DRAIC, inhibits protein translation and induces autophagy by activating AMPK

The paper identifies DRAIC, a tumor suppressive lncRNA, which inhibits NF-kB and activates AMPK-mTOR pathways to suppress cancer progression.

FMRP DIRECTLY INTERACTS WITH R-LOOP AND SHOWS COMPLEX INTERPLAY WITH THE DHX9 HELICASE

This study shows FMRP directly binds R-loops and inhibits DHX9 helicase activity, preventing R-loop accumulation and genome instability in FXS.

EccDNA formation is dependent on MMEJ, repressed by c-NHEJ pathway, and stimulated by DNA double-strand break

This study quantifies eccDNA formation, showing it depends on MMEJ and is repressed by c-NHEJ, with increased levels from DNA breaks and during S-phase.

Investigations of dimethylglycine (DMG), glycine betaine and ectoine uptake by a BCCT family transporter with broad substrate specificity in Vibrio species.

This study identifies dimethylglycine (DMG) as a novel osmolyte for Vibrio parahaemolyticus and shows it is transported by BCCT-family carriers, with BccT1 facilitating uptake of DMG, glycine betaine, and ectoine.

Mapping the adaptive landscape of a major agricultural pathogen reveals evolutionary constraints across heterogeneous environments

The paper maps the adaptive landscape of Zymoseptoria tritici, showing polygenic traits, pleiotropy, and genetic constraints affecting pathogen adaptation across environments.