Native extracellular matrix promotes human neuromuscular organoid morphogenesis and function.
B. Auletta, L. Rossi, F. Cecchinato, G. Barbato, A. Lauroja, P. Chiolerio, G. Cecconi, E. Maghin, M. Easler, P. Raffa, S. Angiolillo, W. Qin, S. Calabro, C. Villa, O. Gagliano, , A. Urciuolo
This study shows that decellularized skeletal muscle ECM guides hiPSC differentiation into structured neuromuscular organoids with functional neuromuscular junctions and disease-mimicking contractility.
bioRxiv · May 19, 2023 · PreprintCell Biology