Potassium channel-driven bioelectric signaling regulates metastasis in triple-negative breast cancer
S. L. Payne, P. Ram, D. H. Srinivasan, T. T. Le, M. Levin, M. J. Oudin
This study shows that altering potassium channel expression changes resting membrane potential in TNBC cells, increasing invasion and metastasis through cadherin-11 and MAPK pathway changes, and suggests repurposing potassium channel blockers as a therapeutic strategy.
bioRxiv · Apr 6, 2021Cancer Biology