M. Levin

Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

The paper identifies SNC80 as a drug that reversibly slows metabolism in Xenopus and demonstrates its cross-species applicability in human organs-on-chips and porcine organs.

Natural Induction: Spontaneous adaptive organisation without natural selection

This paper demonstrates that spontaneous adaptive organisation can arise from the interaction of physical optimisation and learning in dynamical systems, without natural selection.

An ability to respond begins with inner alignment: How phase synchronisation effects transitions to higher levels of agency

The paper uses computational models to show how phase synchronisation of microscale agents leads to emergent higher-level agency through increased problem-solving competency.

Programmable delivery of fluoxetine via wearable bioelectronics for wound healing in vivo

This paper introduces a wearable bioelectronic bandage that delivers fluoxetine on-demand to wounds, reducing inflammation and accelerating healing in mice.

Competitive Amplification Networks enable molecular pattern recognition with PCR

This paper introduces Competitive Amplification Networks (CANs) to enable the analysis of entire gene expression signatures in a single PCR reaction, achieving perfect diagnostic agreement with gold-standard methods.

ZNF524 directly interacts with telomeric DNA and supports telomere integrity

This study identifies ZNF524 as a telomere-binding protein that maintains telomere integrity by supporting TRF2/RAP1 localization and preventing DNA damage and recombination.

Exploring The Behavior of Bioelectric Circuits using Evolution Heuristic Search

This paper uses a heuristic search algorithm to explore bioelectric circuit parameter spaces and identifies parameter sets that produce desired patterning behaviors.

Probing Local Force Propagation in Tensed Fibrous Gels

This study measures force propagation in tensed fibrin hydrogels and shows that force transmission becomes anisotropic with stronger response perpendicular to tension.

Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells

The paper demonstrates that adult human somatic cells can self-construct into motile biobots with diverse behaviors and tissue repair capabilities without genetic modification.

Comparative transcriptomic analysis of whole blood mycobacterial growth assays and tuberculosis patients' blood RNA profiles

The paper compares gene expression in an in vitro whole blood Mtb infection model with tuberculosis patients' blood, identifying concordant and discordant immune responses and their drivers.

Impaired in vitro Interferon-γ production in patients with visceral leishmaniasis is improved by inhibition of PD1/PDL-1 ligation

This study shows that PD1/PDL-1 inhibition increases IFN-γ production in VL patients, suggesting potential for immune checkpoint therapy.

Physarum polycephalum: Establishing an Assay for Testing Decision-making Under Shifting Somatic Boundaries

This study develops an assay using Physarum polycephalum to test decision-making under shifting somatic boundaries, finding that new branches prefer to reconnect with the original mass before exploiting food.

Enhancers of host immune tolerance to bacterial infection discovered using linked computational and experimental approaches

The paper identifies host tolerance mechanisms to bacterial infection using a Xenopus model and multi-omics analysis, finding that metal chelators and HIF-1 agonists enhance survival.

Analysis of Normal Levels of Urine and Plasma Free Glycosaminoglycans in Adults

This study establishes reference intervals for normal plasma and urine free glycosaminoglycans (GAGs) in healthy adults using UHPLC-MS/MS, revealing gender-based differences in GAG concentrations.

Potassium channel-driven bioelectric signaling regulates metastasis in triple-negative breast cancer

This study shows that altering potassium channel expression changes resting membrane potential in TNBC cells, increasing invasion and metastasis through cadherin-11 and MAPK pathway changes, and suggests repurposing potassium channel blockers as a therapeutic strategy.

Immunological factors, but not clinical features, predict visceral leishmaniasis relapse in patients co-infected with HIV

The paper identifies three immunological markers that predict visceral leishmaniasis relapse in HIV co-infected patients, showing they are more predictive than clinical features.

Mechanosensation Mediates Long-Range Spatial Decision-Making in an Aneural Organism

This paper shows that the aneural protist Physarum polycephalum uses mechanosensation to preferentially grow toward heavier, chemically inert masses, revealing a novel biomechanical decision-making mechanism.

Interferon-induced Protein-44 and Interferon-induced Protein 44-like restrict replication of Respiratory Syncytial Virus

This study shows that IFI44 and IFI44L restrict RSV replication and are anti-viral and anti-proliferative, with IFI44L serving as a diagnostic marker for viral infection.

S-adenosylhomocysteine hydrolase regulates anterior patterning in Dugesia japonica

This study shows that SAH hydrolase is essential for anterior patterning in planarians, with inhibition causing tissue regression and apoptosis, but regeneration and metabolic adaptation can overcome these effects.

Nervous System and Tissue Polarity Dynamically Adapt to New Morphologies in Planaria

This study shows how the nervous system in planarians dynamically adjusts tissue polarity to match new organismal anatomies after regeneration.

Defined extracellular ionic solutions to study and manipulate the cellular resting membrane potential

The paper introduces a method to manipulate and study the resting membrane potential in non-excitable cells using defined extracellular ionic solutions and voltage-sensitive dyes.

Lipocalin-2 is a Sensitive and Specific Marker of Bacterial Infection in Children

This study evaluates LCN2 and MMP-8 as biomarkers for predicting serious bacterial infection in children, finding LCN2 to be sensitive and specific with superior performance when combined with CRP.

Single particle diffusion characterization by deep learning

This paper develops a deep learning method to classify and quantify anomalous diffusion processes from single-particle trajectories, outperforming traditional methods with fewer data points.