CXCL8 secreted by immature granulocytes inhibits wildtype hematopoiesis in chronic myelomonocytic leukemia
P. Deschamps, M. Wacheux, A. Gosseye, M. Morabito, A. Pages, A.-M. Lyne, A. Alfaro, P. Rameau, A. Imanci, R. Chelbi, V. Marchand, A. Renneville, M. M. Patnaik, V. Lapierre, B. Badaoui, , D. Selimoglu-Buet
The paper identifies CXCL8 secreted by immature granulocytes as a factor inhibiting wildtype hematopoiesis in CMML, suggesting CXCL8 blockade could slow disease progression.
bioRxiv · Mar 8, 2024Cancer Biology