Heterogeneity in heat shock response dynamics caused by translation fidelity decline and proteostasis collapse
N. Vertti-Quintero, S. Berger, X. Casadevall i Solvas, C. Statzer, J. Annis, P. Ruppen, S. Stavrakis, C. Y. Ewald, R. Gunawan, A. deMello
This study quantifies heat-shock response heterogeneity in C. elegans and identifies translation fidelity and proteostasis collapse as drivers of individual lifespan differences.
bioRxiv · Oct 30, 2019Bioengineering