Author

C. Statzer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Bioengineering· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 4 Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. Y. Ewald· 4 shared A. Chouchane· 1 shared A. Dakhovnik· 1 shared A. deMello· 1 shared A. Goyala· 1 shared A. Kollar· 1 shared A. Longchamp· 1 shared A. Perren· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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4 shared papersPharmacology & Toxicology

C. Y. Ewald

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Patient-derived tumoroids of advanced high-grade neuroendocrine neoplasms mimic patient chemotherapy responses and guide the design of personalized combination therapies

S. L. April-Monn, K. Detjen, P. Kirchner, K. Braeutigam, M. A. Trippel, T. Grob, C. Statzer, R. S. Maire, A. Kollar, A. Chouchane, C. A. Kunze, D. Horst, M. C. Sadowski, J. Schrader, I. Marinoni, , A. Perren

The paper develops patient-derived tumoroids to predict chemotherapy responses and identify synergistic drug combinations for high-grade GEP-NEN.

bioRxiv · Dec 10, 2022 · PreprintCancer Biology

Rilmenidine mimics caloric restriction via the nischarin I1-imidazoline receptor to extend lifespan in C. elegans

D. F. Bennett, A. Goyala, C. Statzer, C. W. Beckett, A. Tyshkovskiy, V. N. Gladyshev, C. Y. Ewald, J. P. de Magalhaes

This study identifies rilmenidine as a caloric restriction mimetic that extends lifespan in C. elegans by activating the I1-imidazoline receptor and modulating pathways involved in stress resistance and autophagy.

bioRxiv · Oct 13, 2021 · PreprintPharmacology & Toxicology

Youthful and age-related matreotypes predict drugs promoting longevity

C. Statzer, E. Jongsma, S. X. Liu, A. Dakhovnik, F. Wandrey, P. Mozharovskyi, F. Zuelli, C. Y. Ewald

The paper identifies drugs that promote longevity by screening for compounds that alter extracellular matrix gene expression and validate them using a collagen-based longevity surrogate marker in C. elegans.

bioRxiv · Jan 26, 2021Pharmacology & Toxicology

ATF-4 and hydrogen sulfide signalling mediate longevity from inhibition of translation or mTORC1

C. Statzer, J. Meng, R. Venz, M. Bland, S. Robida-Stubbs, K. Patel, D. Petrovic, R. Emsley, P. Liu, I. Morantte, C. Haynes, W. B. Mair, A. Longchamp, M. Filipovic, T. K. Blackwell, C. Y. Ewald

The paper shows that ATF-4 and hydrogen sulfide signaling mediate longevity from translation or mTORC1 inhibition in C. elegans.

bioRxiv · Nov 2, 2020 · PreprintPhysiology

Heterogeneity in heat shock response dynamics caused by translation fidelity decline and proteostasis collapse

N. Vertti-Quintero, S. Berger, X. Casadevall i Solvas, C. Statzer, J. Annis, P. Ruppen, S. Stavrakis, C. Y. Ewald, R. Gunawan, A. deMello

This study quantifies heat-shock response heterogeneity in C. elegans and identifies translation fidelity and proteostasis collapse as drivers of individual lifespan differences.

bioRxiv · Oct 30, 2019Bioengineering