Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue
J. Bayram, I. Malcova, L. Sinkovec, J. Holubova, G. Streparola, D. Jurnecka, J. Kucera, R. Sedlacek, P. Sebo, J. Kamanova
This paper identifies an alanine insertion at position 503 in B. pertussis BteA that reduces its cytotoxicity compared to B. bronchiseptica BteA, contributing to attenuated virulence and immune response.
PLOS Pathogens · Aug 10, 2020Peer-reviewedMicrobiology