Early Proteasome Gene Downregulation And Impaired Proteasomes Function Underlie Proteostasis Failure In Alzheimer's Disease
Shan Jiang, Malavika Srikanth, Rossana Serpe, Shadi Yavari, Palavi Gaur, Galen Andrew Collins, Rajesh Kumar Soni, Vilas Menon, Natura Myeku
This study identifies early proteasome dysfunction and transcriptional downregulation in Alzheimer's disease, contributing to proteostasis failure and neurodegeneration.
bioRxiv · Jan 21, 2025 · PreprintPathology