Inflammatory proteolysis generates pathogenic APOL1 fragments with distinct intracellular toxicities in podocytes derived from children with HIV associated nephropathy
Jinliang Li, Ying Yu, Jharna R. Das, Lian Xu, Pankaj Kumar, Zhe Han, Patricio E. Ray
The paper identifies inflammatory proteolysis of APOL1 in podocytes from HIVAN patients, generating toxic fragments with distinct pathogenic functions.
bioRxiv · Aug 17, 2026 · PreprintCell Biology