Structural analysis of HERC2/UBE3A and HERC2/DOCK10 complexes provides new insights into the molecular basis of Angelman, Angelman-like and Dup15q Syndromes
Auguste Demenge, JiaWen Lim, Arpoudamarie Roc, Boglárka Zámbó, Gergő Gógl, A. Cousido-Siah, Alastair G. McEwen, Anna Bonhoure, Camille Kostmann, Christine Fagotto‐Kaufmann, Pascal Eberling, Judit Ősz, ALBERTO D. PODJARNY, Eduardo Howard, Christelle Golzio, , Gilles Travé
The paper analyzes the structural and functional interactions of HERC2/UBE3A and HERC2/DOCK10 complexes to understand their role in Angelman and Dup15q Syndromes.
Nature Communications · Oct 31, 2026Peer-reviewedBiochemistry