AI-Guided Precision in Antibody Humanization: Structural Modeling to Minimize Immunogenicity and Preserve Efficacy
Haiying Wang, Chunqiu Xia, Yupeng Zhu, Yali Wang, Xinxin Chu, Xuemin Pan, Hao Zhou, Zhen Feng Lu, Patrick Doonan, Liang Li, Yunfei Long, Quan Yu
This study uses AI to humanize a murine antibody by grafting only essential paratopes, reducing immunogenicity while preserving efficacy and developability.
bioRxiv · Mar 9, 2025 · PreprintBioengineering