Patrick F Sullivan

A cross ancestry genetic study of psychiatric disorders from India

This study evaluates the predictive accuracy of polygenic scores for psychiatric disorders in an Indian population using European GWAS data, finding moderate-to-high accuracy for bipolar disorder but lower for OCD and externalizing traits.

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

This study connects schizophrenia GWAS findings to specific genes, tissues, and regulatory mechanisms through transcriptome-wide and chromatin activity analyses.

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

This study finds that ultra-rare disruptive variants in highly constrained genes are associated with reduced educational attainment in the general population.

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

The paper uses gene expression data from schizophrenia cases and controls to show that common variants at 20% of schizophrenia risk loci regulate brain gene expression, with functional impacts on neural progenitor cells and zebrafish neuroanatomy.

Integrative approaches for large-scale transcriptome-wide association studies

The paper integrates gene expression and GWAS data to identify novel genes associated with obesity-related traits.

Regulatory variants explain much more heritability than coding variants across 11 common diseases

The paper shows regulatory variants explain significantly more heritability than coding variants for 11 diseases, using imputed data across 218 cell types.