Dynamic Control of Ca2+ Binding in the C2 Domains of Synaptotagmin 1
Patrick J. Rock, Austin G. Meyer, Chantell S. Evans, Edwin R. Chapman, Roger Bryan Sutton
The paper models how AD3 mutations in synaptotagmin 1's C2 domains affect Ca2+ binding pocket dynamics and explains their lethal effects through increased loop mobility and volume changes.
bioRxiv · Sep 10, 2018 · PreprintBioinformatics