Roger B Sutton

This study identifies critical Ca2+ ligands in synaptotagmin 1 for synaptic vesicle exocytosis and reports mutations affecting function.

The paper identifies germ granule-like amyloid/RNA condensates in rat epididymal spermatozoa that exhibit prion-like propagation activity, suggesting a non-Mendelian mechanism for transmitting environmental information to offspring.

The paper identifies the mouse epididymal amyloid matrix as a structural and functional analog of bacterial biofilms, protecting spermatozoa through components like eDNA, eRNA, and mucin-like polysaccharides.

The paper models how AD3 mutations in synaptotagmin 1's C2 domains affect Ca2+ binding pocket dynamics and explains their lethal effects through increased loop mobility and volume changes.