Author

Patrick M. Dooley

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Abigail A. Obeng-MarnuiD· 1 shared Alexandra N. MillsiD· 1 shared Ana Claudia Silva AmaraliD· 1 shared Andreas NeuederiD· 1 shared Benjamin A. DevliniD· 1 shared Bin WangiD· 1 shared Bradley T. HymaniD· 1 shared Christopher M. HenstridgeiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Abigail A. Obeng-MarnuORCID

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2 papers

Recent·Most cited

Divergent Molecular Pathways for Toxicity of Selected Mutant C9ORF72-derived Dipeptide Repeats

Sonia Okekenwa, Ming Ying Tsai, Patrick M. Dooley, Bin Wang, Priscila Comassio, Jorge E. Moreira, Nicola G. Kriefall, Sarah Y. Martin, Gerardo A. Morfini, Scott T. Brady, Yuyu Song

This study identifies compartment-specific toxic effects of C9ORF72-derived dipeptide repeats (DPRs) in neurodegenerative disease models, revealing two distinct pathogenic mechanisms contributing to ALS and FTD.

bioRxiv · Sep 28, 2023 · PreprintNeuroscience

Targeting tau mitigates mitochondrial fragmentation and oxidative stress in amyotrophic lateral sclerosis

Tiziana Petrozziello, Evan A. Bordt, Alexandra N. Mills, Spencer E. Kim, Ellen Sapp, Benjamin A. Devlin, Abigail A. Obeng-Marnu, Sali M.K. Farhan, Ana Claudia Silva Amaral, Simon Dujardin, Patrick M. Dooley, Christopher M. Henstridge, Derek H. Oakley, Andreas Neueder, Bradley T. Hyman, , Ghazaleh Sadri‐Vakili

This study shows that reducing tau with a degrader prevents mitochondrial fragmentation and oxidative stress in ALS models.

Molecular Neurobiology · Nov 10, 2021Peer-reviewedNeuroscience