Divergent Molecular Pathways for Toxicity of Selected Mutant C9ORF72-derived Dipeptide Repeats
Sonia Okekenwa, Ming Ying Tsai, Patrick M. Dooley, Bin Wang, Priscila Comassio, Jorge E. Moreira, Nicola G. Kriefall, Sarah Y. Martin, Gerardo A. Morfini, Scott T. Brady, Yuyu Song
This study identifies compartment-specific toxic effects of C9ORF72-derived dipeptide repeats (DPRs) in neurodegenerative disease models, revealing two distinct pathogenic mechanisms contributing to ALS and FTD.
bioRxiv · Sep 28, 2023 · PreprintNeuroscience