IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection
Yaping Chen, Pengcheng Zhou, Patrick M. Gubser, Yew Ann Leong, Jing He, Yunbo Wei, Fadzai Victor Makota, Mehrdad Pazhouhandeh, Ting Zheng, Joseph Yunis, Zhanguo Li, Axel Kallies, Di Yu
This study shows IL-2 enhances CD8+ T cell effector function but inhibits CXCR5+ TPEX cell formation and follicular infection control in chronic LCMV infection.
bioRxiv · May 2, 2024 · PreprintImmunology