Translating clinical gene sequencing into a foundational representation of tumor subtype
JungHo Kong, Ingoo Lee, Dean Boecher, Akshat Singhal, Marcus R. Kelly, Jimin Moon, Chang Ho Ahn, Chan‐Young Ock, Tannavee Kumar, Timothy J. Sears, David Laub, Sarah N. Wright, Patrick Wall, Hannah K. Carter, Zhen Wang, Trey E. Ideker
This paper introduces MutationProjector, an AI model that converts tumor mutation profiles into cancer subtype representations, achieving strong performance in predicting treatment responses and classifying metastasis.
bioRxiv · Sep 8, 2025 · PreprintSystems Biology