Maayan Baron

The paper shows that desmosome mutations in keratinocytes of the tumor microenvironment promote melanoma proliferation through reduced desmosome gene expression and increased melanoma cell growth.

The paper transplants the human adenine de novo pathway into yeast to study regulatory mechanisms, finding that PPAT/ADE4 is a central regulatory node influenced by metabolites and mutations.

This study integrates single-cell RNA-Seq and spatial transcriptomics data from pancreatic cancer tissue to map cell type spatial distributions and infer tissue architecture.