VC-RDAgent: An efficient rare disease diagnosis agent via virtual case construction informed by hybrid statistical-metric and hyperbolic-semantic prioritization
Yang Liu, Honglei Li, Peng Jiang, Lizhen Wu, Zhi Xie, Chao Ning, Xiangya Kong, Yayun Wang, Xianhu Zhang, Zechi Huang
VC-RDAgent improves rare disease diagnosis by generating virtual cases from knowledge bases, outperforming baselines and enabling offline use.
bioRxiv · Feb 11, 2026 · PreprintBioinformatics