Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms
Perrin Baker, Preston J HIll, Brendan D Snarr, Noor Alnabelseya, Mathew J Pestrak, Mark J Lee, Laura K Jennings, John Tam, Roman Melnyk, Matthew R Parsek, Donald C Sheppard, Daniel J Wozniak, P. Lynne Howell
This study demonstrates that glycoside hydrolases PelAh and PslGh can disrupt and prevent Pseudomonas aeruginosa biofilms by degrading exopolysaccharides, enhancing antibiotic efficacy, and improving immune response.
bioRxiv · Nov 26, 2015Microbiology