EpiTox: A Multi-Modular Framework for Population-Aware Off-Target Prediction Highlighting MAGE-A3 Cross-Reactivity
Hoor Al-Hasani, Mazhar Ali, Stefan Krämer, Kirsten Heiss, Alexander Sinclair, Tobias Herz, Philipp Meyer, Pranav Hamde, Günter Dietmar Roth, Jörg Birkenfeld, Oliver Selinger, Simon Schuster
EpiTox identifies and evaluates pHLA off-targets to improve preclinical safety screening for TCRm therapies, highlighting cross-reactivity with novel epitopes.
bioRxiv · Dec 12, 2025 · PreprintBioinformatics