Author

Alexander Sinclair

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:benchmarking· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Hoor Al-HasaniiD· 3 shared Jörg BirkenfeldiD· 3 shared Oliver Selinger-LutziD· 3 shared Pranav Hamde· 3 shared Simon SchusteriD· 3 shared Stefan KrämeriD· 3 shared Tobias HerziD· 3 shared Christoph ReinhartiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Hoor Al-HasaniORCID

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3 papers

Recent·Most cited

Systematic De-Risking of TCR-Mimic Therapeutics Through Proteome-Wide Off-Target Landscaping and a Generalizable Design Rule Framework

Simon Schuster, Frederike A. Hartl, Jennifer Stehle, Fabian Beier, Hoor Al-Hasani, Christoph Reinhart, Tsai‐Hsuan Weng, Stefan Krämer, Pranav Hamde, Tobias Herz, Sebastian Oesterlin, Marco Schmidt, Tabea Gross, Luca Stehl, Normann Kilb, , Jörg Birkenfeld

This paper introduces ValidaTe, a framework to predict and mitigate off-target liabilities in TCR-mimic antibodies, demonstrating its effectiveness with CTA MAGE-A4 targets.

bioRxiv · Aug 4, 2026 · PreprintImmunology

EpiTox: A Multi-Modular Framework for Population-Aware Off-Target Prediction Highlighting MAGE-A3 Cross-Reactivity

Hoor Al-Hasani, Mazhar Ali, Stefan Krämer, Kirsten Heiss, Alexander Sinclair, Tobias Herz, Philipp Meyer, Pranav Hamde, Günter Dietmar Roth, Jörg Birkenfeld, Oliver Selinger, Simon Schuster

EpiTox identifies and evaluates pHLA off-targets to improve preclinical safety screening for TCRm therapies, highlighting cross-reactivity with novel epitopes.

bioRxiv · Dec 12, 2025 · PreprintBioinformatics

Beyond Sequence Similarity: ML-Powered Identification of pHLA Off-Targets for TCR-Mimic Antibodies Using High Throughput Binding Kinetics

Alexander Sinclair, Stefan Krämer, Christoph Reinhart, Jennifer Stehle, Simon Schuster, Tobias Herz, Hoor Al-Hasani, Pranav Hamde, Oliver Selinger, Jörg Birkenfeld

This paper introduces EpiPredict, a machine learning framework that identifies off-target pHLA interactions for TCRm antibodies beyond sequence similarity, validated through experimental assays.

mAbs · Dec 11, 2025Peer-reviewedImmunology