A CAR T cell-amplified suppressive B cell circuit in AML
Adrian Gottschlich, Vladyslav Kavaka, Thomas Alexander Janert, Veronika Igl, Emanuele Carlini, Lisa Rohrbacher, Wendy den Hartog, Jakob Harwood, Marcel P. Trefny, Selin Sogukcelik, Philipp Penovici, Bernhard Ransmayr, Christian R. Rausch, Franziska Brauneck, Stephanie Frenz-Wiessner, , Sebastian Kobold
The paper identifies suppressive atypical memory B cells in AML that are amplified by CAR T cell interactions and shows that targeting both B cells and AML blasts can overcome this suppression.
bioRxiv · Oct 21, 2026 · PreprintImmunology