Author

Philipp Stephan

Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein design· 1

Frequent Co-Authors

Hajo KriesiD· 2 shared Chloe LangleyiD· 1 shared Daniela WinkleriD· 1 shared Hsin-Mei Huang· 1 shared J. BasquiniD· 1 shared Lorenzo CaputiiD· 1 shared Sarah Ellen O'ConnoriD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 16 mutual co-author links

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2 shared papersSynthetic Biology

Hajo KriesORCID

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2 papers

Recent·Most cited

Directed evolution of piperazic acid incorporation by a nonribosomal peptide synthetase

Philipp Stephan, Chloe Langley, Daniela Winkler, J. Basquin, Lorenzo Caputi, Sarah Ellen O'Connor, Hajo Kries

The paper reports directed evolution of an NRPS adenylation domain to incorporate piperazic acid, demonstrating that low-throughput methods can alter NRPS substrate specificity.

Angewandte Chemie International Edition · Jun 16, 2023Peer-reviewedSynthetic Biology

Engineering DNA templated nonribosomal peptide synthesis

Hsin-Mei Huang, Philipp Stephan, Hajo Kries

This paper describes the engineering of DNA-templated nonribosomal peptide synthetases (DT-NRPS) to enable covalent intermediate channeling and improved catalytic efficiency in biosynthesis.

Cell chemical biology · Nov 24, 2020Peer-reviewedSynthetic Biology