Ping Wang

Role of Uridine Phosphorylase 1 (UPP1) in Pancreatic β-Cell Physiology and Its Dysregulation in Obesity and Type 2 Diabetes

This study investigates the role of UPP1 in β-cell function and shows that UPP1 deficiency impairs uridine-potentiated GSIS and MAPK activation in mice and humans.

POU2AF2/OCA-T1 coactivates POU2F2 and defines a lineage-specific dependency in diffuse large B-cell lymphoma

This study identifies POU2AF2 as a lineage-specific dependency in DLBCL, showing it coactivates POU2F2 to sustain malignant transcriptional networks and innate-like B-cell identity.

Cohesin extrudes chromatin loop unidirectionally through two modes of mechanisms in human cells

The paper investigates cohesin-mediated chromatin loop extrusion in human cells, revealing two dynamic modes of extrusion and showing that CTCF depletion increases extrusion activity.

MetaSAG: A Tool for Multi-level Exploration and Taxonomic Analysis of Microbial Single-Amplified Genomes

MetaSAG provides a tool for multi-level analysis of microbial single-amplified genomes, improving taxonomic classification and enabling functional and evolutionary insights.

Precision CRISPR annotation of the functional enhancer landscape in primary human T cells

The paper develops a CRISPRi platform to annotate functional enhancers in human T cells, identifying novel CREs and their regulatory roles in immune responses.

Multifaceted roles of cohesin in regulating transcriptional loops

This study investigates cohesin's role in transcriptional loops and DNA replication using human cells, finding that cohesin loss affects long-range chromatin interactions and up-regulates early initiation zone genes.

An integrated view of the structure and function of the human 4D nucleome

The paper integrates 4D Nucleome data to analyze 3D genome structure and function in human cells, revealing chromatin domains, loops, and interactions, and showing how genetic variants affect genome folding.