Role of Uridine Phosphorylase 1 (UPP1) in Pancreatic β-Cell Physiology and Its Dysregulation in Obesity and Type 2 Diabetes
YUNQIAN PENG, Lu Ding, Qiutang Xiong, Ling Fu, Chelsea Jang, Yin Wang, Ignacio Norambuena‐Soto, Kevin Wang, Gemin Lu, Erika M. McCown, Eunjin Oh, Lin Tan, Jeffrey Scott Isenberg, Ping Wang, Philipp E. Scherer, , Yingfeng Deng
This study investigates the role of UPP1 in β-cell function and shows that UPP1 deficiency impairs uridine-potentiated GSIS and MAPK activation in mice and humans.
bioRxiv · Sep 28, 2026 · PreprintMolecular Biology