N-Glycosylation is a Potent Regulator of Prion Protein Neurotoxicity
Kevin M. Schilling, Pooja Jorwal, Natalia C. Ubilla‐Rodriguez, Tufa E. Assafa, Jean R.P. Gatdula, Janelle S. Vultaggio, David A. Harris, Glenn L. Millhauser
This study shows that N-linked glycans on PrPC are essential for maintaining a non-toxic structure and suppressing neurotoxicity through intramolecular interactions.
Journal of Biological Chemistry · Jul 27, 2023Peer-reviewedNeuroscience