Cancer BiologybioRxivPreprint
Targeting the dysfunctional mitochondrial respiration in drug resistant B-cell acute lymphoblastic leukemia
R. R. Nair, D. Piktel, P. Thomas…·L. Gibson
This study identifies mitochondrial respiration dysfunction in drug-resistant ALL cells and shows that pyrvinium pamoate (PP) effectively targets this pathway, with enhanced bioavailability and specificity for leukemic cells.
DOI 10.1101/595959