Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma
A. Fernandez, W. Deng, S. L. McLaughlin, A. C. Pirkey, S. Rellick, D. J. Klinke
This study shows that CCN4 promotes immunosuppression in melanoma by reducing CD8+ T cells and increasing MDSCs, and that its removal enhances immune checkpoint therapy effectiveness.
bioRxiv · Feb 23, 2021Cancer Biology