P. Thomas

Pro-survival roles for p21(Cip1/Waf1) in Non-Small Cell Lung Cancer

This study shows that p21Cip1/Waf1 promotes survival and relapse in TP53 wild-type NSCLC by enabling quiescence and protecting cells from chemotherapy.

RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity

This study shows that targeting RBM39 with indisulam promotes natural killer cell activity and eradicates neuroblastoma regardless of cellular state plasticity.

Learning predictive signatures of HLA type from T-cell repertoires

The paper develops a model to predict HLA types from TCR repertoires using associations inferred from HLA-typed donors.

Targeting pediatric High-Grade Gliomas with OAcGD2-CAR Vδ2 T cells

This study evaluates OAcGD2-CAR T cell immunotherapy for pediatric high-grade gliomas, showing Vδ2 T cells outperform conventional β T cells in eliminating tumor cells.

Dynamics of the viral community on the surface of a French smear-ripened cheese during maturation and persistence across production years

The paper studies viral community dynamics on the surface of a French smear-ripened cheese during maturation and across production years, finding persistent dominant phages and shifts in phage-host associations.

Diet-induced obesity impacts influenza disease severity and transmission dynamics in ferrets

This study shows diet-induced obesity in ferrets increases influenza disease severity and transmission due to altered lung microenvironment and reduced antiviral responses.

Spatiotemporal development of the human T follicular helper cell response to Influenza vaccination

This study tracks the spatiotemporal dynamics of human T follicular helper (TFH) cells after influenza vaccination, showing clonal expansion, phenotypic changes, and lineage-specific responses over two years.

Integrated genomic and functional analyses of human skin-associated Staphylococcus reveals extensive inter- and intra-species diversity

This study characterizes the genomic and functional diversity of skin-associated Staphylococcus species using metagenomic and pan-genome analyses, revealing extensive strain-specific gene variation and functional specialization.

Modeling Antigen-Specific T Cell Dynamics Following Hepatitis B Vaccination indicates differences between conventional and regulatory T cell dynamics

This study models T cell dynamics post-Hepatitis B vaccination, revealing differences between conventional and regulatory T cells and their relationship to antibody responses and seropositivity.

Rapid recall and de novo T cell responses during SARS-CoV-2 breakthrough infection

This study examines T cell responses during SARS-CoV-2 breakthrough infections, showing rapid recall of memory T cells and a correlation between CD8+ T cell activation and viral clearance.

A small molecule RIG-I agonist serves to adjuvant broad multifaceted influenza virus vaccine immunity

This paper identifies a small molecule RIG-I agonist, KIN1148, that enhances influenza vaccine immunity by activating non-canonical RIG-I pathways to boost both antibody and T cell responses.

MHC-II molecules present RhoC-derived peptides on the surface of tumour cells

This study shows that RhoC peptides are presented on tumour cell surfaces via MHC-II, suggesting a new antigen presentation pathway relevant to cancer immunotherapy.

Protein Kinase C Delta Regulates Mononuclear Phagocytes and Hinders Response to Immunotherapy in Cancer

This study shows that PKCδ in mononuclear phagocytes suppresses antitumor immunity and response to immunotherapy by reprogramming macrophages and dendritic cells.

Characterization of SARS-CoV-2 public CD4+ αβ T cell clonotypes through reverse epitope discovery

The paper identifies public CD4+ T cell clonotypes reactive to SARS-CoV-2 and predicts their HLA-restriction and epitopes using reverse epitope discovery.

Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline

This study examines the impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline, finding progressive telomere erosion and infertility without bone marrow failure.

Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

The paper infers genetic loci influencing V(D)J recombination probabilities by combining TCR repertoires and genome-wide genotypes from a human cohort.

SARS-CoV-2 mRNA vaccination elicits robust and persistent T follicular helper cell response in humans

This study shows that SARS-CoV-2 mRNA vaccination leads to strong and long-lasting T follicular helper cell responses in humans.

Establishment of a publicly available core genome multilocus sequence typing scheme for Clostridium perfringens

This paper establishes a core genome MLST scheme for C. perfringens and applies it to poultry and non-poultry strains to identify clustering patterns and associations with netB gene carriage and clinical disease.

The impact of Spike mutations on SARS-CoV-2 neutralization

This study evaluates how Spike mutations in SARS-CoV-2 variants affect neutralization by monoclonal and polyclonal antibodies, showing reduced activity in some cases.

High-throughput phenotypic screen for genetic modifiers in patient-derived OPA1 mutant fibroblasts identifies PGS1 as a functional suppressor of mitochondrial fragmentation

This study identifies PGS1 as a genetic modifier that suppresses mitochondrial fragmentation in OPA1 mutant fibroblasts through lipid metabolism modulation.

SARS-CoV-2 Infection And Longitudinal Fecal Screening In Malayan Tigers (Panthera tigris jacksoni), Amur Tigers (Panthera tigris altaica), And African Lions (Panthera leo krugeri) At The Bronx Zoo, New York, USA

This paper reports the first known natural SARS-CoV-2 transmission from humans to animals in the USA, documenting clinical signs, diagnostic findings, and prolonged fecal RNA shedding in tigers and lions.

From people to Panthera: Natural SARS-CoV-2 infection in tigers and lions at the Bronx Zoo

The paper reports the first natural SARS-CoV-2 infections in tigers and lions at the Bronx Zoo, identifying two distinct viral strains and suggesting human-to-animal transmission.

RhoC modulates metabolic networks in cervical cancer by transcriptionally regulating the expression of genes involved in metabolism

This study identifies RhoC's role in modulating metabolic networks in cervical cancer by regulating genes involved in metabolism.

Locally Fixed Alleles: A method to localize gene drive to island populations

This paper proposes a gene drive method to localize population elimination to island populations by targeting locally fixed alleles, showing limited spread to non-target populations.

Targeting the dysfunctional mitochondrial respiration in drug resistant B-cell acute lymphoblastic leukemia

This study identifies mitochondrial respiration dysfunction in drug-resistant ALL cells and shows that pyrvinium pamoate (PP) effectively targets this pathway, with enhanced bioavailability and specificity for leukemic cells.

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptionalprogram in T cell leukemia

This study identifies USP7 as a key driver of T-cell leukemia by stabilizing NOTCH1 and JMJD3, showing USP7 inhibition blocks leukemia growth and suggests it as a therapeutic target.