EnzCast: Prediction of Patient-Specific Enzymatic Kinetics through Multi-Modal Deep Learning and Isoform-Resolved Bayesian Inference based on Single-Cell Transcriptomics
Xuechen Mu, Yi Yang, Qingyu Wang, Zimin Chen, Bizhe Luo, Zhenyu Huang, Xinyi Lin, Long Xu, Xuan Li, Yinwei Qu, Jun Xiao, Zhihang Wang, Bocheng Shi, Qi Ou, Bowen Yao, , Ying Xu
EnzCast predicts enzymatic kinetics from multi-modal data, and IsoKin infers patient-specific in vivo kinetics, showing improved uncertainty reduction in colorectal cancer.
bioRxiv · Apr 30, 2026 · PreprintBioinformatics