A Dynamic Stem Cell State Links Environmental Cues to Skeletal and Regenerative Fates
Yuting Wang, Liming Zhao, Kun Chen, Jinyi Xiang, Ethan J Hunt, Jan Sokol, Ke Ding, Holly M Steininger, Nathan R Martinez, Kelly C Weldon, Edward Chan, David A Morales, Chao Martinez, Sicong Wang, Gabriel Marquez-Arreguin, , Thomas H. Ambrosi
The paper identifies a dynamic stem cell state marked by Panx3 that responds to environmental cues and enables regeneration in aged and osteoarthritic joints.
bioRxiv · Nov 6, 2026 · PreprintCell Biology