Author

Qingfeng Zhang

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Biology Disciplines

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Genomics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Botao LiuiD· 1 shared Heng ZhangiD· 1 shared Hui CheniD· 1 shared Jianbo LiiD· 1 shared Jiang DuiD· 1 shared Jing HuangiD· 1 shared Lihong DingiD· 1 shared Lijia MaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenomics

Botao LiuORCID

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1 paper

Recent·Most cited

Spacer Extension Reconciles Specificity and Activity in High-Fidelity Cas9 Genome Editing

Rong Zheng, Zhike Lu, Rongwei Wei, Young-Cheul Shin, Jiang Du, Qingfeng Zhang, Jianbo Li, Xiaoqi Wang, Yi Wei, Botao Liu, Yang Chen, Lihong Ding, Heng Zhang, Hui Chen, Jing Huang, Lijia Ma

This study shows extending the spacer in SuperFi-Cas9 restores cleavage activity while maintaining specificity, offering a strategy to improve CRISPR efficiency and stability.

Nature Structural & Molecular Biology · Mar 18, 2026Peer-reviewedGenomics