Yang Chen

FlexiTAC enables controllable PROTAC linker generation across diverse structural settings using a Bayesian flow network with posterior guidance

FlexiTAC generates controllable PROTAC linkers using a Bayesian flow network, improving validity and pose quality over existing methods.

Functional orthogonality of WRN inhibitor resistance enables alternating therapy and mutation-tolerant inhibitor design in MSI-H cancers

This study shows that resistance to different WRN inhibitors in MSI-H cancers creates orthogonal vulnerabilities, enabling alternating therapy and mutation-tolerant inhibitor design.

A Broadly Conserved Protective Epitope on the Lyme Disease Vaccine Antigen, OspA

This paper identifies a conserved epitope on OspA that is broadly protective against multiple Borrelia genospecies, suggesting a basis for a universal Lyme disease vaccine.

Systems-level longitudinal immune profiling reveals individualized immunotypes and genetic associations

The paper integrates multi-omics data from 101 individuals over two years to identify stable immune patterns and genetic associations with immune cell types and functions.

Spacer Extension Reconciles Specificity and Activity in High-Fidelity Cas9 Genome Editing

This study shows extending the spacer in SuperFi-Cas9 restores cleavage activity while maintaining specificity, offering a strategy to improve CRISPR efficiency and stability.

AetherCell: A generative engine for virtual cell perturbation and in vivo drug discovery

AetherCell is a generative model that unifies clinical and experimental data to predict drug responses and repurpose existing drugs in human contexts.

CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection

This paper identifies CTHRC1 as a therapeutic target and serum biomarker for aortic dissection, showing it regulates VSMC phenotype and aortic integrity via the ERK1/2 pathway.

The first crested duck genome reveals clues to genetic compensation and crest cushion formation

This study generates a chromosome-level genome of Chinese crested ducks, identifies genetic compensation mechanisms, and reveals the genetic basis of crest formation.

Enrichment-Free Identification of Native Definitive (EnFIND) O-glycoproteome of antibodies in autoimmune diseases

This paper introduces an enrichment-free method to analyze native O-glycoproteomes, revealing high O-glycosylation in antibodies from autoimmune diseases.