Retinal pigment epithelium-derived PD-L1 reprograms microglial cells and protects against retinal degeneration in mouse models of experimental AMD and genetic retinitis pigmentosa
Zhongyuan Su, Jing Wang, Qinghua Lai, Zhenhang Wang, Pingping Liu, Zhiyan Tang, Hang Yu, Yu Chen, Xiaoyin Ma, Ling Hou
This study shows that PD-L1 from retinal pigment epithelium reprograms microglia to reduce inflammation and protect against retinal degeneration in mouse models.
bioRxiv · Jul 26, 2025 · PreprintGenetics