Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions.
R. B. Kumar, P. Purhonen, H. Hebert, C. Jegerschöld
The paper investigates whether arachidonic acid (AA) enables 5-lipoxygenase (5LO) binding to FLAP-containing nanodiscs without calcium ions, finding that AA promotes complex formation independently of calcium.
bioRxiv · Jan 22, 2020Biochemistry