Author

H. Hebert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:protein folding & dynamics· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J.-J. Song· 3 shared P. Purhonen· 3 shared C. Kang· 2 shared S. Hohng· 2 shared S. J. Kim· 2 shared T. Jung· 2 shared A. Abelein· 1 shared A. Fisahn· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiochemistry

J.-J. Song

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Author profile →

6 papers

Recent·Most cited

The membrane-cytoplasmic linker defines activity of FtsH proteases in Pseudomonas aeruginosa clone C

G. D. Mawla, S. M. Kamal, L. Cao, P. Purhonen, H. Hebert, R. T. Sauer, T. A. Baker, U. Romling

This study shows that the MC linker in PaFtsH2 affects its substrate processing efficiency, and modifying it can enhance its function in Pseudomonas aeruginosa.

bioRxiv · Jun 19, 2023 · PreprintBiochemistry

Molecular chaperone ability to inhibit amyloid-derived neurotoxicity, but not amorphous protein aggregation, depends on a conserved pH-sensitive Asp residue

G. Chen, Y. Andrade-Talavera, X. Zhong, S. Hassan, H. Biverstal, H. Poska, A. Abelein, A. Leppert, N. Kronqvist, A. Rising, H. Hebert, P. J.B. Koeck, A. Fisahn, J. Johansson

The paper shows that a conserved Asp residue in BRICHOS domains is critical for inhibiting amyloid toxicity but not amorphous aggregation, with pH sensitivity and evolutionary conservation.

bioRxiv · Dec 1, 2021 · PreprintBiochemistry

CHD7 interacts with the nucleosome acidic patch for its efficient activity via its N-terminal region

E. Lee, C. Kang, P. Purhonen, H. Hebert, K. Bouazoune, S. Hohng, J.-J. Song

This study identifies the N-terminal region of CHD7 as critical for its ATPase activity and nucleosome remodeling through interactions with the nucleosome acidic patch.

bioRxiv · Nov 19, 2020 · PreprintBiochemistry

Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions.

R. B. Kumar, P. Purhonen, H. Hebert, C. Jegerschöld

The paper investigates whether arachidonic acid (AA) enables 5-lipoxygenase (5LO) binding to FLAP-containing nanodiscs without calcium ions, finding that AA promotes complex formation independently of calcium.

bioRxiv · Jan 22, 2020Biochemistry

Structural basis of recognition and destabilization of histone H2B ubiquitinated nucleosome by DOT1L histone H3 Lys79 methyltransferase

S. Jang, C. Kang, H.-S. Yang, T. Jung, H. Hebert, K. Y. Jung, S. J. Kim, S. Hohng, J.-J. Song

The paper presents cryo-EM structures of DOT1L with nucleosomes and shows H2B ubiquitination enhances DOT1L's non-catalytic nucleosome destabilization function.

bioRxiv · Dec 31, 2018Biophysics

Integrative structure investigation on the architecture of human Importin4_histone H3/H4_Asf1a complex and its histone H3 tail binding

J. Yoon, S. J. Kim, S. An, A. Leitner, T. Jung, R. Aebersold, H. Hebert, U.-S. Cho, J.-J. Song

This study investigates the structure of the Importin4_histone H3/H4_Asf1a complex and identifies key interactions between Importin4 and the histone H3 tail.

bioRxiv · Sep 6, 2017Biochemistry