Transmembrane helices are an overlooked and evolutionarily conserved source of major histocompatibility complex class I and II epitopes
R. Bilderbeek, M. Baranov, G. van den Bogaart, F. Bianchi
The paper shows that transmembrane helices are a conserved source of MHC-I and II epitopes, leading to over-presentation of membrane protein-derived peptides in immune responses.
bioRxiv · May 2, 2021Immunology